Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Effects of Metformin, Insulin on Hematological Parameters of COVID-19 Patients with Type 2 DiabetesArticle Published on 2022-10-012023-07-11 Journal: Medical archives (Sarajevo, Bosnia and Herzegovina [Category] COVID19(2023년), [키워드] COVID-19 diabetes insulin metformin. [DOI] 10.5455/medarh.2022.76.329-332 PMC 바로가기
COVID-19 and diabetic ketoacidosis: A case series at an urban district hospital in South AfricaArticle Published on 2022-09-222022-11-16 Journal: South African Family Practice [Category] 치료기술, [키워드] Admission age appear biochemical Care case sery clinical outcomes Comorbidities Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 infected patient COVID-19 infection detect diabetes Diabetic diabetic ketoacidosis district hospital. glycaemic control HbA1c hemoglobin HIV hospital Human immunodeficiency virus hypertension hypoxia hypoxic IMPROVE insulin male median age monotherapy Mortality Patient presenting Prevalence profiles ranged required risk factor South Africa study period the patient therapy type 2 diabete [DOI] 10.4102/safp.v64i1.5590 PMC 바로가기
Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways긴 COVID에서 삶의 질 저하가 정동 증상, 만성 피로 증후군, 염증 및 신경 면역 독성 경로에 의해 예측됩니다Article Published on 2022-08-192022-09-11 Journal: International Journal of Environmental Research an [Category] 바이오마커, [키워드] Activation acute infection Affect Anxiety AstraZeneca Biomarker body temperature calcium caspase caspase-1 chronic chronic fatigue syndrome controls COVID COVID-19 Depression domain Effect explained fatigue fatigue syndrome female fibromyalgia Health Organization IL-18 immune Inflammation inflammatory biomarkers insulin insulin resistance life Long Long COVID Myalgic encephalomyelitis/chronic fatigue syndrome myeloperoxidase neuro-immune neurotoxicity oxidative stress oxygen oxygen saturation participant pathway Pfizer physical predicted Protein psychiatry Psychiatry. Psychological Quality Quality of life rating scales recruited Regression serum severity Sex SpO2 subsequent Switzerland vaccination variance Version World Health Organization yielding [DOI] 10.3390/ijerph191610362 PMC 바로가기 [Article Type] Article
Case report: SARS-CoV-2 infection as a trigger for diabetic ketoacidosis and newly detected pancreatic autoantibodiesArticle Published on 2022-08-102022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Altered mental status antibody autoantibodies autoantibody autoimminity beta-hydroxybutyrate blood glucose collected coronavirus CoV COVID COVID – 19 diabete Diabetes Mellitus Diabetic diagnosed Diagnosis discharged home Follow-up increased risk Infection infection with SARS-CoV-2 insulin nausea pancreatic past medical history positive regimen SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection Shortness of breath T1D type 1 diabetes (T1D). type 2 diabete vomiting [DOI] 10.3389/fendo.2022.983206 PMC 바로가기
Risk factors for COVID-19 case fatality rate in people with type 1 and type 2 diabetes mellitus: A nationwide retrospective cohort study of 235,248 patients in the Russian FederationObservational Study Published on 2022-08-092022-10-05 Journal: Frontiers in Endocrinology [Category] 임상, [키워드] 95% confidence interval absence age agonist anti-COVID-19 vaccination association atherosclerotic BMI body mass index cardiovascular disease Case fatality rate CFR Chronic kidney disease CKD clinical information Combination COVID-19 COVID-19 case database death diabete Diabetes Mellitus Dipeptidyl peptidase-4 disease Factor fatality Fatality rate Federation Glucose-lowering drug glucose-lowering therapy. group Increased inhibitor inhibitors insulin Laboratory male Observational cohort study Odds ratio Older age outcome Patient patients positive receptor Registered retrospective cohort study risk risk factor risk of death therapy type 2 diabete vaccination Vaccine was performed were used [DOI] 10.3389/fendo.2022.909874 PMC 바로가기 [Article Type] Observational Study
Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic ReviewReview article Published on 2022-08-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] 임상, 진단, [키워드] added article clinical guideline Cochrane Library conducted Controlled trial COVID-19 COVID-19 pandemic database Dexamethasone diabetes effective End points evaluated glucocorticoid hyperglycemia Including insulin management objective Patient patients with COVID-19 RCT RCTs regimens Respiratory Support Result review Standard of care steroid Support synonym systematic review treatment strategy variety Web of Science widespread [DOI] 10.1016/j.eprac.2022.07.014 [Article Type] Review article
Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?지질 비율과 트리글리세리드-글루코스 지수는 COVID-19 환자의 중환자 치료 결과와 관련이 있습니까?Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] adjusted age Analysis biochemical marker biochemical markers BMI carried cholesterol coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 mortality COVID-19 patient Critical care demonstrated evaluate Glucose HDL-C high-density insulin insulin resistance LDL-C Lipid lipoprotein Logistic regression analysis low-density Low-density lipoprotein Mortality multivariate multivariate logistic regression analysis outcome performed predictor Prognosis Regression regression models Research severe coronavirus disease Severe patient severe patients severity Sex significantly higher significantly lower statistically survivor Total cholesterol Triglyceride with COVID-19 [DOI] 10.1371/journal.pone.0272000 PMC 바로가기 [Article Type] Article
Association of triglyceride-glucose index with prognosis of COVID-19: A population-based studyCOVID-19의 예후와 트리글리세리드-글루코스 지수의 연관성: 인구 기반 연구Article Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] MERS, 바이오마커, 진단, [키워드] 95% confidence interval adjusted adjusted odds ratio calculated Care Chain Reaction complications of COVID-19 Composite COVID-19 COVID-19 cohort COVID-19 infected patients COVID-19 infection COVID-19 patient COVID-19 patients dataset defined diagnosed diagnosis of COVID-19 Diseases evaluated fasting glucose Glucose Health health screening high-flow oxygen therapy increased risk infected patients Infection Infectious diseases insulin insulin resistance intensive care marker Mean ± standard deviation mechanical ventilation Mortality multivariate logistic regression outcome oxygen Oxygen therapy patients patients with COVID-19 polymerase chain polymerase chain reaction Primary outcome Prognosis Prognostic value reverse transcription reverse transcription polymerase chain reaction risk factor severe complication severe complications severity of COVID-19 shown Standard deviation Triglyceride Triglyceride-glucose index. [DOI] 10.1016/j.jiph.2022.06.014 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article